This morning, I was receive an sms form my best friend who preach the the US Food and Drugs Administration (FDA) has retract drugs which is containing Phenylpropanolamine (PPA). Because the PPA has been caused brain haemorrhage. Phenylpropanolamine (PPA) is a synthetic compound of the sympathomimetic amine structurally similar to presor amines epinephrine, phenylephrine, aphedrine stimulation and central nervous system like ephedrine and amphetamine. In Indonesia, PPA is found in cough and influenza medicines. Of course, almost all hundreds influenza medicines brands is contains PPA.

Due to this time I have influenza and is being consume Neozep Forte (which after I read in the box it’s contain 15 mg of PPA), of course, I surprised and a little panic. So, I browse the Google to find more information.

And I can take lessons as follow:


In fact, this PPA case is not a new case. According to this link, PPA was recalled in United States since 2000. Its was followed by Malaysia and Singapore. Because in these countries PPA not only use as decongestant (influenza medicine), but also produced as a mixture of loose weight drugs (PPA can also press appetite).

Meanwhile, other countries such as European, Japan, Philippines, and Australia does not recall PPA from the market. Indonesia, based on meeting of Komnas POJ (December 5, 2000), allows use of PPA only as an active influenza and cough medicine. However, the dosage is reduced, from 25 mg per dose to 15 mg per dose. And since April 16, 2001, Indonesia (BPOM) has banned the circulation of all drugs which is containing phenylpropanolamine (PPA) more than 15 mg per dose.

I’m a little relieved, because Neozep Forte which I consume is contain 15 mg of PPA, still on secure limit from BPOM. But considering of the side effects that can be caused by PPA is egregious enough, it seems I may not take the medicine too easy :D

My suggestion is always note the information listed in the drug package. If necessary, check the information about one of every substance in the drug. The information I mean is about the function and side effects, safe dose or the maximum safe dose per day. For PPA, based on this link, the dose allowed in Indonesia much less than the dose allowed in UK and US. That is 10-25 mg per dose. Usage per day is allowed a maximum of 75 mg for adults and 37.5 mg for children 6-12 years and is not recommended for children under the age of 6 years.